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Sultan A, Steven D, Rostock T, et al

The SURPASS-1 trial demonstrated significant improvements in glycemic control and substantial reductions in body weight with all three doses of tirzepatide (5 mg, 10 mg, or 15 mg) compared to placebo over a 40-week period

In a 2003 study by Khavinson et al

39 , 40 Leukotrichia, the presence of a localized patch of white hair, is, therefore, a poor prognostic sign in vitiligo patients, and vitiliginous areas with overlying leukotrichia may require more aggressive therapies to achieve successful repigmentation

UV light exposure is the primary risk factor for the development of melanoma, and fairskinned individuals (Fitzpatrick 3) are at increased risk of melanoma independent of pharmacologic activation of MC1R