Patients who monitor only weight and ignore blood sugar, blood pressure, lipid levels, and inflammatory markers miss important signals about when to continue, taper, or adjust treatment
14,16,17 These integrated actions support glucose homeostasis and contribute to body weight reduction
In addition, evidence from recent experimental studies suggests that most GLP-1 analogues can be injected peripherally and absorbed into the brain, indicating that they could cross the blood-brain barrier (BBB) and exert physiological influences directly on the human brain (72) (detail seen Box 2 )
Semaglutide safely helps patients lose weight and avoid setbacks caused by emotional eating with once-per-week injections
This rebound effect is not unique to GLP-1 receptor agonists, but has also been observed with other pharmacotherapies, such as orlistat and phentermine [8,9]