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Blood-Brain Barrier Penetration and CNS Distribution Achieving sufficient CNS concentrations is a critical pharmacokinetic requirement for a procognitive compound, and Dihexa's peptidomimetic design addresses this challenge

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Gadolinium chloride (GdCl 3 ), a lanthanide compound, depletes KCs irreversibly and has been widely used in research

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Based on available information, some specific molecules with expected properties can be synthesized and tested

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