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There were fewer women of reproductive age, so it is possible that some menstrual-related side effects were not noticed or were too rare to show up clearly

Gonzlez F, Rote NS, Minium J, Kirwan JP

Still, the same substudy reported absolute lean mass reductions of several pounds in some arms, a reminder that any large caloric movement carries lean tissue with it unless training and protein intervene

Dosage Forms: Oral tablets: 10 mg, 25 mg Indications: Type 2 Diabetes Mellitus Reduction of cardiovascular death in patients with T2DM and established CVD Reduction in hospitalization for heart failure Spectrum / Benefits: Improves glycemic control Lowers cardiovascular risk Reduces heart failure hospitalization Offers renal protective effects Common Side Effects: Urinary tract infections Genital mycotic (yeast) infections Increased frequency of urination Serious Risks: Euglycemic diabetic ketoacidosis (rare) Volume depletion & hypotension Acute kidney injury (in predisposed patients) Drug Interactions: Diuretics increased risk of dehydration Insulin or insulin secretagogues risk of hypoglycemia Food Considerations: Can be taken with or without food Maintain adequate hydration Avoid excessive sodium intake Clinical Tips: Assess renal function before initiation Ensure proper hydration Educate patients about early signs of DKA and genital infections Educational content for healthcare professionals only