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These receptors predominantly couple to the stimulatory protein G s , leading to cyclic adenosine monophosphate (cAMP) production (de Graaf et al., 2016), but they can also engage alternative signaling pathways and exhibit pronounced ligand-dependent biased agonism (Wang et al., 2018)

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The design of this agonist is based on a deep understanding of the structure and signaling pathways of these receptors, allowing a molecule to bind to its specific receptor and simulate the action of natural ligands, thereby activating downstream signaling pathways of the receptor

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