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Animals in the negative control group (CTR) were maintained on a standard commercial rat chow, whereas the other three groups were fed a high-glucose, high-fat diet consisting of 15% fat, 10% sucrose, 3% cholesterol, 3% sodium chloride, and 69% standard feed for eight week according to Ramuet al., (2021) 59

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Therefore, the use of a dual GLP-1/GIP receptor agonist might reduce hyperglycemia, thereby restoring the glucose-lowering effects of GIP [14]

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