glutathione reactive oxygen species (ROS) are generated by the mitochondria as a Photothermal theranostics with glutathione depletion

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Interestingly, insulin and IGF-I share many structural and functional similarities implying that they have originated from the same ancestral molecule

Science 293 , 11551159 (2001)

Glutathione can act as a reducing agent mediated by an enzyme or otherwise in an oxidation reaction which leads to the direct conversion of GSH to its oxidised form of GSSG

In addition, the powerful loading of plant-based antioxidants also helps reduce depletion of existing L-glutathione from stress