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US approves first GLP-1 pill for weight loss: Novo Nordisk WASHINGTON - Danish pharmaceutical giant Novo Nordisk announced on Dec 22 the US Food and Drug Administration (FDA) had approved its popular GLP-1 anti-obesity drug Wegovy to be administered in pill form for weight loss

only 1 high-quality RCT evaluated the effects on fatigue, making it impossible to estimate the meta-analysis 111

It is a triple hormone receptor agonist on the GLP-1, GIP, and glucagon receptors

Prime examples include limiting intakes of caffeine and alcohol (which interfere with liver detox of estrogen), increasing dietary fiber intakes (to limit intestinal deconjugation of excreted estrogen metabolites), and increasing consumption of phytoestrogens

Mitigation strategies include diluting shots with additional bacteriostatic water or mixing with BPC-157, which reportedly reduces injection discomfort