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hnRNP-A2 also stimulated lymph node cells to produce inflammatory cytokines in a MyD88-dependent manner, and overexpression of hnRNP-A2 in the PIA rats joints during the acute and chronic phases was found in synoviocytes of the inflammatory pannus tissue, chondrocytes of articular cartilage, and osteoclast-like multinucleated cells, inducing resorption of cortical bone during both phases of PIA (110)
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