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Naturally, metabolomic profiling has found extensive use in the diagnosis and treatment of IEMs, although the test has also helped establish new or previously unrecognized aspects of several other genetic conditions, as well (3436)

Rai MK, Shekhawat NS, Harish GAK, Phulwaria M, Ram K, Jaiswal U (2011) The role of abscisic acid in plant tissue culture: a review of recent progress

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established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present