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It is unproven whether BPC-157 causes receptor downregulation in humans

See Pros and Cons of Using PRP for Tendon Injuries Prolotherapy This treatment involves administering small amounts of a medicated solution, such as dextrose or saline, into the rotator cuff tissue(s) over a period of several weeks with the goal of inducing tissue regeneration, promoting healing, and reducing pain

Food and Drug Administration and isnt legally intended for human use, but rather for laboratory research

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Oral BPC-157 has a credible biological rationale specifically for gastrointestinal injury, where local mucosal exposure may be the mechanism rather than systemic absorption