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The number of self-reported current somatic diseases (including cardiometabolic, respiratory, musculoskeletal, digestive, neurological, endocrine diseases and cancer) for which participants received medical treatment was counted (coded as 0, 1, 2+) as a global marker of poor physical health

Conclusion: NGT carriers of the T2D-associated genetic variant rs111669836 are characterised by diminished incretin effect and low OGTT-induced GLP-1 secretion whereas carriers of the rs17791513 G allele have significantly higher incretin effect and lower BMI than non-carriers

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50 On the other hand, the injection of insulin antibodies into the hypothalamus of rats heightens food intake and leads to body weight gain

The upregulation of SLC25A11 could have several implications for cellular metabolism in ME/CFS