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[52] While elders are more sensitive to GH, and thus more susceptible to the side effects of replacement with rhGH, stimulating production and secretion of endogenous GH with Sermorelin offers the advantage of a more physiological approach to increasing GH pulsatility while reducing risk for side effects

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Arndt GM, Dossey L, Cullen LM, Lai A, Druker R, Eisbacher M, et al

Small molecules such as carbohydrates, amino acids, and hormones pass across the BBB using endothelial carrier-mediated transporters (Oldendorf, 1971), while macromolecules such as transferrin and insulin use endothelial receptor-mediated transport (Banks, 2012)