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specifically examined patients with MASLD cirrhosis and type 2 diabetes, finding that GLP-1 receptor agonist initiation was linked to reduced risk of unfavorable liver outcomes including hepatic decompensation events and mortality from any cause (aHR: 0.78, 95%CI: 0.68-0.90) relative to non-users, suggesting potential benefits even in advanced liver disease populations [58]

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Some clinical centers administer, besides the LNAAs in the Phe free medical mixtures, an additional dose of 0,5 to 1 g LNAAs per kg bodyweight to treat the excessive Phe levels in adult PKU patients