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A Team of Antioxidants at Work Beyond glutathione, sauna heat has been linked to higher levels of other antioxidants like superoxide dismutase and catalase

Notably, an ongoing RCT investigating the effects of semaglutide on pre-treatment cognitive dysfunction in patients with major depression may provide useful insights in this regard (NCT04466345 (ref

Se is an enzymatic antioxidant that has no antioxidant effect by itself but participates in selenoproteins as redox-active selenoenzymes to safeguard against oxidative damage (172, 173)

Phase 2 trial data (Jastreboff et al., NEJM, 2023) showed mean body weight reductions of approximately 24% at 48 weeks with the highest dose, with no clear plateau observed

The PICOs elements were defined as follows: P (Participants): subjects of any age diagnosed with Vitamin B12 deficiency