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Very common side effects (affecting more than 1 in 10 people): Nausea Often the most troublesome side effect, typically improving over several weeks Diarrhoea Can range from mild to moderate

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These immunomodulatory properties may enhance the effectiveness of conventional biologic therapies and could potentially support disease control in early PsA, although this possibility still requires confirmation in dedicated clinical studies, a phase in which immune dysregulation is still evolving

An F1-targeted mouse was bred with a tissue-specific Camk2a-Cre deletion mouse to generate F2

The blot is representative of 3 independent experiments