You should contact your GP or seek specialist referral if you are experiencing: Unexplained weight gain or difficulty losing weight despite lifestyle changes Symptoms that may suggest growth hormone deficiency , such as persistent fatigue, reduced muscle mass, increased abdominal fat, or low mood formal biochemical testing is required before any treatment is initiated Poorly controlled blood glucose or a new diagnosis of type 2 diabetes Interest in weight-management medicines , to discuss licensed options available through NHS or regulated private pathways access to weight-management pharmacotherapy on the NHS is typically via specialist weight management services, subject to local eligibility criteria Seek urgent medical attention via NHS 111 or, if necessary, 999 if you experience severe or persistent abdominal pain (which may indicate pancreatitis), signs of a serious allergic reaction, chest pain or palpitations, or symptoms of diabetic ketoacidosis (extreme thirst, frequent urination, confusion, or vomiting)
Return the remaining medication to the fridge
It's worth noting that GLP-1 receptor agonists rarely cause hypoglycaemia unless combined with insulin or sulfonylureas, so this is an unlikely cause of headaches for most patients
The long-term side effects of semaglutide are less common but can be more serious
This adjustment phase typically passes as your system recalibrates
