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Potential side effects include local skin irritation, contact dermatitis, and theoretical drug interactions if systemic absorption occurs

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Potential interventions include pharmacological agents ( e.g ., aminoguanidine, metformin, phenylthiazolidine, and pyridoxamine), dietary modifications ( e.g ., low-AGE diets), and regular physical exercise (81, 82)

For example, weight loss drugs are excluded from coverage from the government programs Medicaid and Medicare