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"Use of metformin should be restricted to those patients with glucose intolerance." Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Side Effects and Safety Profile One major drawback of metformin is its gastrointestinal side effects , such as nausea, diarrhea, and abdominal pain

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Timelines vary by compound and symptom

Conclusions The highest chance of a clinical pregnancy or live birth occurred with -hCG levels of 253 IU/L (92.7% chance of clinical pregnancy and 74.5% chance of a live birth, at 13dp3dt or 11dp5dt)

As shown in Figure 5, the GH neuroendocrine axis involves many levels of feedback control including long, short and ultra-short loops