Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies
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Research by Te-Sheng Chang found the lowest levels of reduced glutathione to be associated with eumelanin-type pigmentation, whereas the highest ones were associated with pheomelanin
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LA (DH-LA) can directly scavenge ROS and reactive nitrogen species (RNS), thereby reducing oxidative damage [36]