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The potential explanation for sex differences in the IGF-1 signaling pathway on aging as well as response to other age-delaying interventions is unclear, but unique interactions of candidate pathways and targets with sex hormones could explain in part these disparate effects

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(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray

Mattioli R, Ilari A, Colotti B, Mosca L, Fazi F, Colotti G

Notably branded as Wegovy for weight management and Ozempic for type 2 diabetes, semaglutide is now also available as an oral tablet, the Wegovy pill, offering flexibility for those preferring to skip injections