Anticancer Res 37(4):1705 Kaczmarzyk I, Nowak-Perlak M, Woniak M (2024) Promising approaches in plant-based therapies for thyroid cancer: an overview of in vitro, in vivo, and clinical trial studies
As a transcription target of p53, the activity of spermidine/spermine N 1 -acetyltransferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism, induces lipid peroxidation and sensitizes cells to undergo ferroptosis and the deletion of SAT1 suppresses p53 and p53 3 KR -mediated ferroptosis
The percentage of late apoptosis in THJ-16 cells increased from 5.49% for untreated cells to 63.43% for treated cells, while the corresponding percentage in CAL-62 cells increased from 16.72 to 69.88%
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