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Those who discontinued the medication regained most of their lost weight within a year

Nutritional Deficiencies The mechanism that makes GLP-1 medications effective, slowing digestion and reducing food intake, can also lead to significant nutritional gaps: Many patients consume fewer calories, making it difficult to obtain adequate nutrients Altered digestive processes may reduce the efficiency of nutrient absorption Key nutrients at risk include calcium, vitamin D, B vitamins, iron, and protein 4

Funding This work was carried out with the financial support of Medical University of Lodz

doi: 10.1016/j.cell.2019.10.031 5 BeekenR

A sample semaglutide taper from a therapeutic dose might look like this