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He J, Lu Y, Song X, Gong X, Li Y
Site-specific PEGylation involves covalent attachment of polyethylene glycol (PEG) chains to predefined residues on the peptide backbone, forming a hydrophilic steric shield that reduces renal clearance, masks immunogenic epitopes, and protects against enzymatic degradation [189]
The pathophysiology involves dysregulated immune responses, genetic susceptibility, environmental triggers, and alterations in the gut microbiome
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