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The exact mechanism remains unresolved after decades: no specific receptor, precursor gene, or biosynthetic pathway has been definitively identified

Role of neurokinin type 1 receptor in nociception at the periphery and the spinal level in the rat

Phase II Clinical Trials These promising preclinical findings led to Phase I and Phase II clinical trials in humans

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Also, MAOB-KO + PTSD groups exhibited decreased S100-positive areas, S100 intensity, and astrogliosis compared to both MAOB-WT + PTSD and OE + PTSD groups (Fig