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But as powerful as it is, it's still working primarily on the visible symptoms and pathways at the skin's surface

While compromised barriers pathological, creates opportunity for peptide therapy during active disease phases

According to NICE guidance (NG28), these medications have demonstrated significant benefits in glycaemic control, with some specific agents (semaglutide, liraglutide, dulaglutide) also showing cardiovascular risk reduction in clinical trials

IGF-1 signaling is anabolic: it promotes muscle protein synthesis and inhibits protein breakdown, helping preserve lean muscle

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