glp-1 receptor agonists benefits and drawbacks of agonist use. Abbreviations: Many patients taking glucagon-like peptide-1

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This effect is not observed in other GLP-1RAs and is currently being studied by the drug manufacturers in the FOCUS trial (NCT03811561)

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Although oxidative damage in biological systems has in the past been completely attributed to ROS, it is becoming increasingly clear that also reactive nitrogen species (RNS) and reactive sulfur species (RSS) are integral components of signal transduction processes in cells, and play important roles in OS generation [2, 25, 35]