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Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations

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[Abstract]2024 Jul 15;69(13):2122-2135

Introduction Glutathione S -transferases (GSTs) refer to a group of cytosolic phase II detoxification enzymes, which have both a GSH-binding site and a substrate-binding site (H-site) that catalyze the nucleophilic attack of the sulfur atom of glutathione (GSH) on electrophilic groups of substrate molecules ( S -transferase Pi (GSTP) is the most abundant member of cytosolic GSTs in the mammalian cells ( via its non-catalytic ligand-binding activity

Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR