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Compared to the standard cultivation temperature (30 C), both elevated (37 C) and reduced (23 C) temperatures exerted measurable effects on the biomass of the recombinant (Fig

1 Although oral and perioral pigmentation may be physiologic in nature, particularly in individuals with a darker complexion, throughout the course of disease it is possible for the oral mucosa and perioral tissues to assume a variety of discolorations, including brown, blue, gray, and black

In a human study ( n = 6), 62 3% of an ingested dose of tritium labelled ergotamine was absorbed and the mean urinary elimination half-life of ergotamine was 31 5 h (Aellig and Nesch 1977)

The authors reported no conflicts of interest related to the study

Weight loss typically plateaus after 12 to 18 months, but this reflects reaching a new metabolic equilibrium rather than medication failure