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Biphasic dose-response A pattern where a compound stimulates growth at low concentrations but inhibits it at higher concentrations

10.4103/jrms.JRMS_236_20 Summary Keywords L-carnitine, glycemic markers, systematic review, meta-analysis, adult, diabetes mellitus type 2 Citation Zamani M, Pahlavani N, Nikbaf-Shandiz M, Rasaei N, Ghaffarian-Ensaf R, Asbaghi O, Shiraseb F and Rastgoo S (2023) The effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis

25 However, the difference between the NAC and the placebo group failed to reach statistical significance

However, oral bioavailability is much lower than injectable, meaning the doses are higher (3 mg, 7 mg, and 14 mg tablets compared to the 0.25 to 2.4 mg injectable range)

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