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Nadolsky says that for some of his patients at the highest dose of tirzepatide, the drug is sometimes "dampening that dopamine reward system down so much that now, instead of just getting away from those addictive behaviors, they don't feel like doing anything." Some of those high-dose patients start seeking out sugar, not due to cravings, he says, but because their bodies are searching for some kind of stimulation to get the reward system going again

LOX reaction rate was calculated as the slope of fluorescence increase over time