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In the beginning, demographic information and records of diseases, medications, and dietary supplements were acquired from the patients
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The typical age of onset in the 2nd and 3rd decade of life ( By analyzing the reactivity of a TCR from a lesional psoriatic CD8 + T-cell clone rearranging the V3S1 and V13S1 variable region genes characteristic of infiltrating lesional CD8 + T cells (V3S1/V13S1 TCR) ( + T cells in lesional psoriatic epidermis indeed react against melanocytes, as indicated by the V3S1/V13S1 TCR ( + T cells activated against melanocytes in psoriasis cause chronic inflammation through the production of IL-17 and IL-22 ( A suspected mechanism for self-reactive T cells to evade peripheral tolerance mechanisms is through the antigen recognition mode of TCRs
The mean age of the participants was 50 years old, and they were mostly females (61%
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