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Initial assessments should include comprehensive metabolic panels, lipid profiles, pregnancy testing when applicable, and screening for contraindications

In addition, Reye's syndrome is diagnosed when there are no other reasonable explanations for the brain and liver abnormalities ( This case report described a child with MIC-S, who underwent IVIG and ASA treatment and deteriorated after 1 week of treatment, with an altered level of consciousness, seizures, normal CSF, laboratory-proven hepatic changes, and no explanations to justify the brain and liver changes

Many types of MMPs are involved in arterial remodeling and BP regulation, including MMP-1, 84,85,86 MMP-2, 87,88,89 MMP-3, 90,91 MMP-9 81,89,92,93 etc

As summarized in Fig