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They do not typically interfere with the injectable form itself

As with all prescription medicines, there are rare but important risks, including pancreatitis, gallbladder disease and worsening diabetic retinopathy in susceptible individuals

Beyond direct pharmacological interactions, other factors warrant consideration

[17] Other organisms require additional metals as enzyme cofactors, such as vanadium in the nitrogenase of the nitrogen-fixing bacteria of the genus Azotobacter , [18] tungsten in the aldehyde ferredoxin oxidoreductase of the thermophilic archaean Pyrococcus furiosus , [19] and even cadmium in the carbonic anhydrase from the marine diatom Thalassiosira weissflogii

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