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Therefore, SGLT2-i diuretic properties show a major advantage compared to thiazides and thiazides-like diuretics, which act on the Na + CL - -cotransporter in the distal convoluted tubule, or loop diuretics, which block the Na-K-2Cl co-transporter of both the Henle loop and the macula densa, making the macula insensitive to the increased tubular sodium coming from the Henle loop

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