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GLP-1 has anorexic effects via direct or indirect activation of nucleus arcuate neurons [78] and activates the POMC and CART neurons through the control of AMPK

Genetic mutations that inhibit MC4R signaling lead to hyperphagia, decreased energy expenditure, and early-onset obesity, highlighting the receptor's fundamental importance in metabolic control

One of the most potent clinical benefits of GLP-1s for weight loss is their ability to prevent type 2 diabetes, a condition they also successfully treat