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The arrival of FDA-approved Foundayo (orforglipron) changes part of that equation

Experimental models demonstrate that circadian disruption precipitates steatosis and fibrosing steatohepatitis even under standard dietary conditions, while environmental and behavioral disruptors including ALAN, shift work, SJL, short sleep duration, and chrononutritional misalignment exacerbate adverse metabolic phenotypes closely aligned with MASLD risk

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So, they require an adequate supply of CoQ10 for optimal functioning