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HGF also reduces the number of astrocytes by retaining the levels of the glial-specific glutamate transporter 1, thus favoring a reduction in glutamatergic neurotoxicity (Sun et al., 2002)

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More recently, a breakthrough 2026 study utilizing both in-vitro cellular models and an in-vivo human pharmacokinetic trial further solidified these findings

Sikiric et al., 2018), and its role in the braingut and gutbrain axis (Sikiric et al., 2016), along with its CNS-disturbances therapy (Sikiric et al., 2016) and stress disorders (Sikiric et al., 2017