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Review of Cardiovascular Outcomes Trials of Sodium-Glucose Cotransporter-2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists

In rodents, central GLP-1 receptor activation stimulates sympathetic outflow to adipose tissue, induces thermogenic gene programs, and promotes browning of white adipose depots ( In humans, however, BAT mass is limited, heterogeneous, and reduced in obesity, and even maximal activation contributes only modestly to total energy expenditure (31)

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At higher doses, semaglutide is marketed as Wegovy for weight management in adults with obesity or overweight with comorbidities