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Primary and secondary outcome measures Following model development and internal validation, primary outcome measures included model performance statistics for discrimination (C-statistic) and calibration (calibration slope and calibration-in-the-large) for pain-improvement models for each of the five clinically meaningful pain domains

While opioids and painkillers are often necessary for patients in pain, they come with significant risks and concerns

In 2026, federal mental health parity laws and expanded telehealth mandates have broadened access for many BCBS members

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DKD is characterized by intestinal barrier dysfunction (leaky gut) and metabolic endotoxemia, creating a vicious cycle that sustains systemic inflammation and kidney injury