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For young, otherwise healthy individuals taking the drug solely for weight loss, the equation is less clear, and a frank discussion with a physician about absolute versus relative risk is warranted

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Combination Therapy : The synergistic effect is promising, but clinical validation in humans remains limited

Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls

Enzymatic degradation: The gastrointestinal tract contains various proteases and peptidases, such as pepsin, trypsin, and chymotrypsin, which can rapidly degrade orally ingested protein drugs, rendering them biologically inactive