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Beyond nausea, the gastrointestinal side effect cluster includes diarrhea, vomiting, constipation, and decreased appetite, which is technically a desired effect but can become problematic at extreme levels

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Originally developed to improve glycemic control in type 2 diabetes, drugs like semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound) have proven remarkably effective at helping patients lose weight

Cindy Mosbreer: Uh, I had a patient once who would bleed out of her ear every time she had her patient

With liraglutide, mean pulse rate rose slightly from randomization in the first 30 weeks of the trial (Figure 3c), but subsequently fell, approximately to screening levels (Figures 3b and c)