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Telomerase is also active in cancer cells, and while the mechanisms differ from its role in healthy aging, anyone with a history of cancer or a strong genetic cancer risk should discuss this carefully with a provider before considering epithalon

Deficiencies of other enzymes are rarer and have highly variable clinical phenotypes that may be specific for each enzymatic defect

[Abstract]2025 Dec 10;44(12):116671

While the study establishes a compelling systemic role for SLC25A45 in fuel switching, important questions remain regarding the tissue-specific contributions of this pathway and how carnitine biosynthesis and utilization are differentially regulated across dietary, disease, and sexually dimorphic contexts