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The North American Academy of Cosmetic Surgery provides a set of numerical standardized dosing guidelines

[71] Excessive consumption of antioxidant supplements has been connected to greater death rates and an increased risk of developing several types of cancer

Tang Q, Zheng G, Feng Z, Chen Y, Lou Y, Wang C, et al

This corresponds with other studies that suggest a decreased HRV is present in ME/CFS, indicative of a chronically high sympathetic tone (78, 330, 332344)

Metsera has a nice slide on this below, and assuming their calculations are true, this COGs delta could prove to be a valuable commercial advantage