While meningococcal interactions on the surface of epithelial and endothelial cells have been intensively investigated, leading to the identification of key determinants of virulence of this bacterium, relatively little is known about the crossing of the nasopharyngeal epithelial barrier (NEB), the BBB, and BCSFB by the meningococcus
therefore, use during breastfeeding should be approached with caution
Liposomal formulations encapsulate glutathione in phospholipid vesicles, potentially improving intestinal absorption compared to standard capsules
151,152 The mechanism of IAPP-induced cell death may also include inflammation and oxidative stress
In turn, this phenomenon can triggers a catalytic mechanism for the oxidation of the cellular thiol pool [117,118,119] and of oxidative stress when the homeostatic compensation is overwhelmed by an excessive depletion of the reduced thiol pool, as is the case for cells, such as neurons, that depend on neighboring glial cells for their supply of essential thiol precursors