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A neuroimaging study suggested that depression strongly leads to memory dysfunction given that morphological changes in the brain of depressed patients, such as atrophy and abnormal alteration of the frontal cortex, thalamus, and hippocampus, is related to cognitive impairment (Zhang et al., 2016)

112 However, histological assessments are recognized to have variability in pathological readings and an unignorable placebo response

doi: 10.1016/j.celrep.2019.07.107 75 LiuXCaoZWangWZouCWangYPanLet al

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The overall direction of these changes moves gene expression patterns from states associated with disease and aging toward healthier profiles