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10.1007/s40273-021-01072-z 38 KanokeA.NishijimaY.LjungbergM.OmodakaS.YangS

Interestingly, in EA.hy926 cell death was already significantly reduced upon knockdown of either Bim or Bid, most probably due to a more efficient knockdown of Bid and Bim compared to skHep-1 (Supplementary Figure 2)

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1) 2) CANCER : methotrexate is a structural analog of folic acid and at the high concentrations used in cancer chemotherapy it competitively inhibits the binding of dihydrofolic acid to dihydrofolate reductase (Furst et al., 2012)

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