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This line or research is not entirely surprising given that patients with colitis/Crohn's disease have a much higher rate of colon or bowel cancer (Blackstone 1981 Blackstone, M

171 Notably, DON showed the ability to significantly inhibit the generation and recruitment of MDSCs and to reprogram M2-like TAMs into proinflammatory TAMs, which increased tumor antigen cross-presentation to T cells and enhanced the efficacy of immune checkpoint blockade (ICB)

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