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While mild to moderate fatigue is common with GLP-1s, it should not be debilitating

With less of this protective layer, UV radiation may penetrate more directly, and the skin may feel more exposed, fragile, or sensitive to the touch, leading to an intensified perception of sun exposure

Keeping a symptom diary can be helpful for clinical assessment

PLoS ONE 10:e0140883 Missailidis D, Annesley SJ, Allan CY et al (2020) An isolated complex V inefficiency and dysregulated mitochondrial function in immortalized lymphocytes from ME/CFS patients