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Polymeric nanoparticles are engineered for controlled drug release, responding to specific stimuli in the tumor microenvironment for precise drug delivery and regulate gene expression [24]

GLP-1 receptor agonists work by slowing gastric emptying, increasing satiety signals, and reducing hunger-driven eatingbut over time, the body's internal systems recalibrate to these new conditions

Even if GLP-1s have lower efficacy than an existing treatment (and there are indications that they may have higher efficacy), if they can reach many times more people, the overall public health impact would be massive

2025 Jun;274:24-31

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